Metformin vs. Berberine – Why Berberine is Called Nature’s Metformin Berberine has been shown in studies to be just as effective as metformin at lowering blood sugar by improving insulin sensitivity and activating AMPK, your body’s metabolic master switch. But unlike metformin, berberine comes without common side effects like nausea and bloating. Taking metformin and berberine together has been shown to lead to a much more significant decline in blood sugar levels than taking metformin alone. Al