eLife

Multiscale dynamical characterization of cortical brain states: from synchrony to asynchrony

We conclude that brain states are shaped by local circuit mechanisms, large-scale connectivity and neuromodulation. A unified multiscale theory of cortical dynamics is relevant not only for ...
eLife

State-dependent brain responsiveness, from local circuits to the whole brain

This correspondence between brain state and brain responsiveness (statedependent responses) is outlined at different scales from the cellular and circuit level, to the mesoscale and macroscale level.
eLife

Modulating task outcome value to mitigate real-world procrastination via noninvasive brain stimulation

This potentially valuable cross-sectional longitudinal study leverages high-definition transcranial direct current stimulation to the left dorsolateral prefrontal cortex to examine its effect on ...
eLife

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States ...
eLife

Continuous flashing suppression of V1 responses and the perceptual consequences revealed via two-photon calcium imaging and transformer modeling

Two-photon imaging and ocular dominance mapping. A. Optical windows for imaging of two macaques. Green crosses indicate the regions for viral vector injections, and yell ...
eLife

Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

Harm and responsibility differentially shape guilt and shame, which in turn drive compensatory behavior to varying extents.
eLife

Persistent contacts between Climp63 and microtubules cause mitotic defects and nuclear fragmentation

This important study reveals that mitotic release of an ER-microtubule tether is critical for normal mitotic progression. Manipulating CLIMP63 phosphorylation, the authors provide convincing evidence ...
eLife

Cardenolide toxin diversity impacts monarch butterfly growth and sequestration

This important study shows that different forms and mixtures of cardenolide toxins in tropical milkweed, especially nitrogen- and sulfur-containing types, change how monarch caterpillars eat, grow, ...
eLife

Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

This study provides useful insights into addressing the question of whether the prevalence of autoimmune disease could be driven by sex differences in the T cell receptor (TCR) repertoire, correlating ...
eLife

A dynamic scale-mixture model of motion in natural scenes

Some of the most important tasks of visual and motor systems involve estimating the motion of objects and tracking them over time. Such systems evolved to meet the behavioral needs of the organism in ...
eLife

Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

Exogenous attention is a rapid, involuntary mechanism that automatically reallocates processing resources toward salient stimuli. It enhances visual sensitivity in the vicinity of the salient stimulus ...
eLife

Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

This valuable study provides solid evidence for deficits in aversive taste learning and taste coding in a mouse model of autism spectrum disorders. Specifically, the authors found that Shank3 knockout ...