49ers vs. Colts prediction, odds, pick for Week 16 Monday Night Football

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.
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49ers’ real mission isn’t stopping Colts’ Philip Rivers, it’s slowing Jonathan Taylor

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.