The San Francisco 49ers defense will face Philip Rivers on Monday night. The 44-year-old recently came out of retirement to ...

INDIANAPOLIS — The Indianapolis Colts and San Francisco 49ers understand the stakes on Monday night. Both find themselves in ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

Yahoo Fantasy and Arena Club have teamed up to bring you a brand new experience – weekly Yahoo Fantasy Slab Packs featuring top-performing fantasy football players. If you’re new to Arena Club, here’s ...

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Brock Purdy and the San Francisco 49ers will play the Indianapolis Colts at Lucas Oil Stadium on ESPN on Monday, December 22, ...

Brock Purdy looks to build off his best start of the season, Dak Prescott tries to keep the troops focused with the season ...

The Indianapolis Colts are just trying to get into the playoffs. The San Francisco 49ers are playing for a division title and ...

2. Matthew Stafford, L.A. Rams: The leader in the clubhouse for MVP, Stafford can break the Rams’ tie with Hall of Famer Kurt ...

On one hand, there was speculation of a quarterback controversy, as 49ers backup quarterback Mac Jones performed increasingly ...