Using an AI-driven approach, researchers found DNA within nucleosomes is often partly exposed, enabling nuanced gene regulation through multiple structural states, and offering insights into disease, ...

Researchers have discovered that DNA wrapped around nucleosomes exists in multiple partially open states rather than simply locked or accessible configurations.

A new study upends the long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases. SAN FRANCISCO—April 29, 2026—Every ...

A new AI-powered analysis by Gladstone Institutes and the Arc Institute has found that most nucleosomes—the protein clusters that package DNA—contain sections of DNA that remain partially accessible, ...

Biomolecular condensates play important roles in cellular organization and function, but their internal structures remain poorly understood due to limitations in imaging techniques. This is true for ...

Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

This manuscript reports important data on the stability of nucleosomes with dsDNA substrates containing defined mismatches at three defined nucleosomal positions. Compelling evidence obtained by ...

This manuscript provides a useful reconstruction of the structure of the sirtuin-class histone deacetylase Sirt6 bound to a nucleosome based on cryo-EM observations, and additional characterization of ...