Severe posttransfusion hyperhemolysis in a sickle cell patient produced profound anemia and lactic acidosis; terminal complement blockade with eculizumab stabilized hemolysis and enabled recovery.

Andes virus, found in South America, is the only currently known hantavirus for which limited human-to-human transmission ...

Higher serum lactate dehydrogenase (LDH) levels are associated with significantly worse renal and cardiovascular outcomes in patients with advanced chronic kidney disease (CKD) without diabetes, ...

A healthy 25-year-old man presents with a painless testicular mass. Ultrasound revealed a 5 cm solid mass, appearing to replace the left testicle. A left radical orchiectomy is performed.

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Many coaches argue that lactate threshold is one of, if not the, biggest performance predictor. It determines how fast you can run longer distances without burning out. So, a key component of training ...

Clinicians frequently follow blood lactic acid/lactate levels in ICU patient management to assess and monitor tissue hypoxia, sepsis, cardiogenic shock, severe volume depletion, and additional ...

What Is Lactate Dehydrogenase (LDH)? The enzyme LDH, also called lactic acid dehydrogenase, is in almost all body tissues. It helps the body turn glucose (sugar) from food into usable energy for our ...

Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...