Photocatalytic hydrogen evolution is a key technology for clean energy conversion, in which platinum (Pt) is widely used as an effective cocatalyst. The anchoring and dispersion of Pt play a decisive ...

Researchers examine the thermodynamic properties of the interaction of the histamine H1 receptor with geometric isomers of the antihistamine drug doxepin Recently, the importance of drug design based ...

Our study reveals the underlying principles governing the passive membrane permeability in three large N-methylated macrocyclic peptides (N-MeMPs): cyclosporine A (CycA), Alisporivir (ALI), and ...

Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, Manauli PO, S.A.S. Nagar, Mohali, Punjab 140306, India Article Views are the COUNTER-compliant ...

Abstract: Dear Editor, This letter deals with a solution for time-varying problems using an intelligent computational (IC) algorithm driven by a novel decentralized machine learning approach called ...

Thalidomide, one of the most infamous drugs of all, caused severe birth defects in the children of pregnant women who took the drug for nausea in the 1950s. Its story has been repeated over and over – ...

London-based Isomer Capital, a private investment firm focused exclusively on European venture capital, announced on Monday the first close of its latest €250M fund, Isomer Capital III (IC III). The ...

Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding ...

The effects a drug or chemical compound have on the body depend on how its atoms are arranged in space. Some compounds have a dark twin with the same molecular formula but different 3D structure – and ...

Various [3.3.3]metacyclophane derivatives were synthesized from 6,15,24-tri-tert-butyl-9,18,27-trimethoxy [3.3.3] metacyclophane-2,11,20-trione 1 using simple chemical reactions. The conformations of ...