Human organoids are 3D cell cultures derived from adult stem cells and maintain the variable distribution of epithelial cells seen in primary tissue. They can recapitulate the mechanisms of epithelial ...

Years before he conducted the research that would earn him a Nobel Prize in Physiology and Medicine, Shinya Yamanaka, MD, ...

Cells on the inner surface of the intestine are replaced every few days. But, how does this work? It was always assumed that cells leave the intestinal surface because excess cells are pushed out. In ...

For decades, physicians and scientists thought metformin, the leading Type 2 diabetes medication taken by millions worldwide, ...

Researchers at the Francis Crick Institute have shown that the Cryptosporidium parasite exports a protein into infected intestinal cells, altering the gut environment and enabling the parasite to ...

A study published in the journal Nature, led by Carlene Zindl, Ph.D., and C. Garrett Wilson in the research group of Casey Weaver, M.D., at the University of Alabama at Birmingham, brings new ...

Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy. By targeting senescent cells that build up over time, the treatment boosted gut regeneration, ...

A new preclinical study from Weill Cornell Medicine found that the protein caspase-5 (CASP5), long thought to be a foot ...

Eating is one of life’s few constants: If you’re not eating right now, you’ll certainly be eating something within a few hours. But when and how often we should eat is still not fully understood.

A stem cell-derived intestine model reveals glycyrrhizin as a potential treatment for inflammatory bowel disease.

When inflammation damages the intestinal lining, differentiated enterocytes and crypt base columnar stem cells (CBCs) revert to a regenerative, fetal-like state and form revival stem cells (revSCs).