Aldose reductase (AR) has been a long-standing target for treating diabetic complications, but its structural similarity to related enzymes has made selective inhibition difficult. Off-target binding ...
Researchers from ICTER have developed a fragment-based drug discovery method combined with microcrystal electron diffraction to design enzyme inhibitors at atomic resolution. The approach aims to ...
9d
No more guesswork in drug design—atomic-resolution method exposes what trial and error keep missing
Drug discovery still too often relies on expensive trial and error. Researchers from ICTER show there is another way—building ...
Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands, Department of Tanning Materials & Proteins, National Research Centre, 12622-Dokki, Cairo, Egypt, ...
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