New research shows the X chromosome influences disease risk, immunity and drug response beyond its role in sex.

Extra X chromosomes significantly increase the risk for systemic lupus erythematosus (SLE) and Sjögren disease, with the prevalence of these conditions being higher among patients with Klinefelter and ...

X-linked agammaglobulinemia (XLA) is an immune disorder that causes extremely low levels of B cells, which are an important part of the immune system. XLA can put a person at risk of frequent ...

“This work is really important because the X chromosome has largely been excluded from genetic studies in the past,” said Amy Roberts, a molecular epidemiologist at King’s College London who was not ...

X chromosome reactivation contributes to reducing the signs of disease in the female brain. Female cells have two X chromosomes and male cells have one X chromosome and one Y chromosome. So that the ...

Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have identified a mechanism that protects the female brain from genetic diseases. Although one of the two X chromosomes is ...

X-linked hypophosphataemia (XLH) is the most prevalent heritable form of rickets in children and of osteomalacia in adults.

Height is one of the most evident sex-based differences observed in humans, as men are on an average 13 cm (5 inches) taller than women. Sex hormones certainly play a significant role in driving this ...

Individuals that share the same deletion of a portion of chromosome 16 are at risk of developing neurodevelopmental disorders ...