The Wnt signaling pathway, a system present in living organisms, plays a pivotal role in cell growth, differentiation, and migration. It has a long history dating back to 1982, when the first Wnt gene ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...

The Wnt signalling network is a central regulator of cellular proliferation, differentiation and tissue homeostasis. In cancer, aberrant activation of canonical and non-canonical branches of Wnt ...

Wnt signalling is a well-known mode of cell-to-cell communication in multicellular biological organisms. It involves the secretion of small Wnt glycoproteins, by signalling cells, that bind to ...

Researchers from the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have identified a previously ...