Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource
Research in gene therapy involving genome-integrating vectors now often includes analysis of vector integration sites across the genome using methods such as ligation-mediated PCR (LM-PCR) or linear ...
In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus–based γ-retrovirus vector expressing interleukin-2 receptor ...
In the past few years, with the availability of near-complete sequences for several vertebrate genomes, the targeting of retroviral DNA integration has been subjected to genomic analysis. These ...
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