Renal drug excretion involves filtration, reabsorption, and secretion, crucial for drug clearance and minimizing toxicity. The study models renal clearance using pharmacokinetic parameters, validated ...

Acidosis affects sodium and potassium excretion, likely via the pH sensitivity of ion transporters. A recent paper shows that β-intercalated cells with deleted H +-ATPase release ATP into urine, which ...

The pattern of transport of penicillin G and carbenicillin was examined directly in the rat kidney by means of micropuncture studies. Samples of plasma, tubular fluid, and urine were assayed for ...

This is the solution to a case we presented recently. You may review the case here. The patient had complained of dyspnea, and an abnormal electrolyte panel revealed a decreased bicarbonate level of ...

Seufert et al. (Dec. 27 issue) 1 describe a man with tumor-induced (oncogenic) osteomalacia, in which the subcutaneous administration of octreotide abolished renal tubular phosphate wasting. The ...

Nephrotoxicity is defined as the rapid deterioration in kidney function as a result of medications and chemicals. Nephrotoxicity can also be defined as an adverse event caused by substances that ...