How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

For the first time, scientists at Albert Einstein College of Medicine have developed a technology allowing them to "see" single molecules of messenger RNA as they are translated into proteins in ...

In this valuable study, the authors develop new approaches to investigate mRNA imprinting, a phenomenon in which RNA-protein complexes form in the nucleus to influence the fate of transcripts in the ...

Double-stranded RNA (dsRNA) is a well-recognized byproduct of in vitro transcription that poses significant challenges for the use of synthetic mRNA in research and therapeutic applications. Even ...

Our study progresses from the rational design of polyplex micelles to the mechanistic elucidation of mRNA degradation, revealing RNase infiltration—rather than carrier dissociation—as the principal ...

A new artificial intelligence model can improve the process of drug and vaccine discovery by predicting how efficiently specific mRNA sequences will produce proteins, both generally and in various ...

In vitro transcribed mRNA has lived up to its potential as a game-changing disruptive vaccine modality during the COVID-19 ...

Subtle differences in an mRNA sequence enables a ribosome to produce more or less of a certain protein. A new AI model called RiboNN predicts which sequences will be most efficiently produced and ...

Bivalent EABR mRNA boosters broaden neutralizing responses to Omicron subvariants by promoting diverse receptor-binding domain epitope targeting, although antibody responses remain partially shaped by ...