Scientists engineered CMLase, an enzyme that removes CML, a form of age-related protein damage linked to tissue stiffness and inflammation. The enzyme was created through five rounds of directed ...

Collagen begins losing its internal organization before skin shows visible signs of aging, thinning, or damage. Researchers used advanced light-based imaging to measure collagen’s chirality, fiber ...

A team of medical researchers at the National Children's Medical Center, Children's Hospital, Fudan University, in China, has developed a technique to freeze and thaw brain tissue without causing ...

Frostbite and related cold-induced tissue injuries arise from ice crystal formation, microvascular compromise and inflammatory reperfusion damage. Clinical management begins with prompt assessment of ...

A new study by Vanderbilt investigators has uncovered a previously unknown biological mechanism: how tissues detect and respond to damage in basement membranes, the thin layers of extracellular matrix ...

A new study published in Nature Communications reveals a novel approach to mitigating tissue damage caused by Streptococcus pyogenes, the flesh-eating bacterium responsible for severe infections such ...

The ability to repair tissue following injuries is essential for the survival of all animals. Following wounding, the skin is repaired by activating, migrating, and dividing skin stem cells. Defects ...

Cedars-Sinai scientists have developed an experimental drug that repairs DNA and serves as a prototype for a new class of medications that fix tissue damage caused by heart attack, inflammatory ...

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent and alleviate periodontal tissue damage. The research demonstrates that ...

A blast injury is physical trauma caused by the rapid pressure wave and associated fragments generated by an explosion. 1,2 The resulting blast wave compresses air within open and enclosed spaces, ...

Basement membranes are extracellular matrices—flat sheets of protein and carbohydrate—that are essential for tissue architecture and function. But like all tissues, they are subject to damage. Until ...