Glucocorticoid receptors (GRs) are ligand-activated transcription factors that play a pivotal role in mediating the effects of endogenous and synthetic glucocorticoids. These receptors regulate a ...

Using a powerful single-molecule imaging method they developed, a Broad Institute research team has unveiled a dynamic view ...

T cell receptors (TCRs) are fundamental to the adaptive immune system, playing a pivotal role in recognising and responding to pathogenic challenges. Generated through the process of V(D)J ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of these ORs in lab settings—leaving them with a murky understanding of how ...

Scientists know that smell depends on a vast library of receptors, each tuned to different odor molecules. But they could not ...

The inside of a mouse’s nose looks chaotic under a standard microscope: millions of sensory neurons packed into a thin, mucus ...

"I think PAGER has potential for impact, both in the G protein coupled receptor biology field, and in synthetic circuits or cell-based therapies," said Alice Ting, professor of genetics at the School ...

Edited by Karen Young Kreeger J.A. Bennett, R. Dingledine, "Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop," Neuron, 14:373-84, ...

A poorly characterized protein, historically thought to be a chaperone or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, ...

For most of us, the sense of smell is an integral part of everyday life; it plays a critical role in providing information ...

Mosquitoes are the most dangerous animals in the world. The diseases they transmit have spread death and misery since time immemorial. Aedes aegypti is a particularly treacherous mosquito because it ...