Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...
While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...
Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...
Scientists from Duke-NUS Medical School and their international collaborators have developed a new computational tool that ...
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The enzyme that doesn't act like one: NUDT5 controls DNA building block production through structure, not catalysis
Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules. A central part of this network is folate metabolism, a process that ...
Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...
NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.
A novel computational tool has been used to identify a metabolic weakness in acute myeloid leukemia, offering a new drug ...
(Vienna, 6 November 2025) Inside every cell, a finely tuned metabolic network determines when to build, recycle, or stop producing essential molecules. A central part of this network is folate ...
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