Nature

Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis

Hypoxia-elicited adaptations of tumor cells are essential for tumor growth and cancer progression. Although ample evidence exists for a positive correlation between hypoxia-inducible factors (HIFs) ...
ascopubs.org

Will Prolyl Hydroxylase Inhibitors Supplant Erythropoiesis-Stimulating Agents and IV Iron in the Treatment of Chemotherapy-Induced Anemia?

In the article that accompanies this editorial, the authors' trial results indicate that roxadustat, a proline hydroxylase inhibitor, was noninferior to erythropoiesis-stimulating agent therapy in ...
Healio

Hypoxia-inducible factor prolyl hydroxylase inhibitors have emerging role in anemia management

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. On February 12, the FDA accepted its first new drug ...
ascopubs.org

Prolyl hydroxylase domain 1 (PHD1) to mediate chemoresistance in colorectal cancer.

Clinical significance of serum claudin-7 levels in patients with colorectal cancer. Use of FLIM histology-based HER2-HER3 heterodimer quantification and a Bayesian latent class proportional hazards ...