Carbohydrates with high glycaemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum ...

Using a gas chromatography–mass spectrometry (GC–MS) method with stable isotope internal standards, 3 we measured concentrations of sorbitol and its polyol pathway metabolite, fructose, as well as ...

Rapid and extensive Schwann cell death under high-glucose pyruvate-depleted conditions can be evoked by the following sequential metabolic alterations; 1) diminished TCA cycle intermediates and ...