ascopubs.org

Paired matched normal sequencing to accurately identify somatic clonal hematopoiesis mutations (CHm) in solid tumor tissue and plasma specimens.

ctDNA as a biomarker in phase II study of tepotinib in advanced solid cancers with MET exon 14 skipping mutation or amplification (KCSG AL19-17). Characterization of molecular response and progression ...
ascopubs.org

Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction

TP53 Gain-of-Function and Non–Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma The study used whole-exome sequencing of tumor sample ...
Labroots

Concordance of targeted sequencing from circulating tumor DNA and paired tumor tissue

In this study, we evaluated the concordance of targeted sequencing results between paired ctDNA and tumor samples from early breast cancers scheduled for curative surgery with or without adjuvant ...
BioTechniques

Characterizing genomic and epigenomic variation between tumor–normal research samples using long nanopore sequencing reads

Genomic instability is characteristic of most cancers. To explore this, paired tumor–normal whole-genome sequencing can be used to gain deeper understanding of genomic and epigenomic variability in ...
GEN

Recent Advances in NextGen Sequencing

Illumina just released new sequencing chemistry kits and complementary software for its Genome Analyzer system. These new products reportedly enable researchers to generate 40% more reads per run and ...