Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts ...

Bisphosphonates decrease bone resorption and are commonly used to treat or prevent osteoporosis. However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients ...

Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. The findings from University of Virginia School of ...

Trends in real-world clinical outcomes among patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC) treated with liposomal irinotecan based regimens in the United States (US). This is an ...

The number of Americans stricken by a deadly and debilitating bone-thinning disease continues to climb. According to a 2004 Surgeon General's report, more than half of Americans age 50 and older are ...