For decades, KRAS, one of the deadliest cancer-causing mutant proteins, has been considered impossible to target due to its ...

Today, doctors are increasingly looking at the genetic makeup of each patient’s tumor to guide treatment decisions.

Mutations in a protein called KRAS fuel some of the most lethal cancers. Designing drugs to disable KRAS has proved ...

PYNNACLE enrolled heavily pretreated TP53 Y220C–mutant ovarian cancer (median four prior lines), including platinum-resistant ...

Imagine a tiny superhero inside every cell of your body whose job is to stop damaged cells before they turn dangerous. That superhero is a gene called TP53, and for decades scientists have known it as ...

Zongertinib provided substantial clinical benefit for patients with advanced or metastatic HER2-mutant advanced non-small cell lung cancer, surpassing the historical standard of care efficacy for this ...

A fresh and important book reveals the messy reality of our ever-mutating cells – and why the quest to defeat ageing is ...

Discover how TP53 mutations in adult leukaemia impact treatment outcomes and potential strategies for improved patient care.

The study investigated r ezatapopt (PC14586), a first-in-class small molecule designed to selectively bind and reactivate the ...

Some of your most important life partners are the mitochondria that power all your cells. You and these little cellular ...