This image compares three DNA sequencing technologies: Sanger sequencing, Massively Parallel DNA sequencing, and Nanopore DNA sequencing. Sanger sequencing (left) sequences 500-700 bases per reaction ...

DNA methylation is a highly studied epigenetic modification that regulates genome function and plays key roles in development and disease 1. It is linked to a broad range of conditions, including ...

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome. Transposons play critical roles in immune response, ...

Janina Krumbeck, PhD, discusses the clinical advantages of next-generation sequencing over traditional culture and how this untargeted diagnostic approach provides comprehensive pathogen ...

Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...

In a breakthrough that redefines both speed and clinical potential, a new world record for the fastest human whole genome sequencing has been set. Think of all the things that can be done in four ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

When the COVID-19 pandemic was at its peak, and multiple variants were threatening lives around the world, scientists relied ...

The researchers deeply sequenced five head and neck squamous carcinomas, four lung squamous carcinomas, and one colorectal adenoma.

In a French criminal trial, conventional DNA analysis couldn’t distinguish between twin brothers, but emerging scientific methods could help in such cases.

Genome editing using CRISPR/Cas9 "gene scissors" is a powerful tool for biological discovery and for identifying novel drug targets. In pooled CRISPR screens, a large number of cells are edited ...