“This work is innovative because our use of sophisticated technologies to examine genomic and epigenetic mechanisms of gene regulation will lead to new discoveries into salivary gland organogenesis ...

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands. Cell Reports, 2022 DOI: 10.1016/j.celrep.2022.110663 ...

SRY-box transcription factor 9 (SOX9) gene regulates the development of both mouse and human salivary glands. In its absence, the salivary glands cannot undergo branching morphogenesis.

Salivary Gland Disease The major salivary glands produce approximately one quart of saliva each day, which in turn plays a crucial role in food digestion, swallowing, speech, and protection of teeth ...

Salivary gland cancer is a rare disease where cancerous cells form in the tissues of the salivary glands. Signs & Symptoms These are signs of salivary gland cancer: Fluid draining from the ear A lump ...

The major salivary glands (i.e., parotid, submandibular, sublingual) are affected 80%-85% of the time. Approximately 64% to 80% of all salivary gland tumors occur in the parotid gland.

Approximately 75% of parotid gland tumors are benign, but less than half of submandibular tumors are benign. Most neoplasms of the minor salivary glands are malignant.

Like some other parts of the body, the salivary glands have what is known as “immune privilege,” meaning that even though they are infected, the immune system may not effectively clear pathogens ...

So far, no recurrent chromosome rearrangement, gene fusion, or common mutation has been encountered in these tumors. 3 However, a recent study unexpectedly showed that conditional inactivation of the ...

Radiation therapy, a common treatment for some oral cancers, can leave a patient’s salivary glands so damaged that even talking is difficult. Meanwhile, diseases such as Sjogren’s, which eradicates ...