If either high sensitivity cardiac troponin (hs-cTnT) or coronary artery calcium (CAC) are elevated, the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) climbs substantially, which ...

A new molecular mechanism associated with arrhythmias (abnormal heart rhythms) has been discovered. Scientists report that increased calcium sensitivity of the heart cell's contractile apparatus ...

Abnormal heart rhythms – arrhythmias – are killers. They strike without warning, causing sudden cardiac death, which accounts for about 10 percent of all deaths in the United States. Vanderbilt ...

From your morning stretch to your fastest sprint, every movement depends on the precise dance between actin, myosin, and calcium inside your muscle fibers. Scientists are uncovering not only the ...

Animals used in this study were handled according to the animal welfare regulations of Duke University (Durham, NC). The protocol was approved by the Institutional Animal Care and Use Committee. The ...

Cardiac troponin concentrations are used to identify patients who would benefit from urgent revascularization for acute coronary syndromes. We hypothesized that they might be used in patients with ...

In most patients with stable coronary artery disease, plasma cardiac troponin T levels are below the limit of detection for the conventional assay. The distribution and determinants of very low ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of ...