A new study has shed light on how the most common known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) — a GGGGCC-repeat expansion in C9orf72 — exerts its toxic effect ...

An inflammatory sugar molecule produced by certain gut bacteria may play a key role in driving ALS, a study found.

What goes wrong in the brain of a person with a hexanucleotide expansion in C9ORF72, a protein involved in RNA processing? Quite a bit, according to an analysis published in the July 20 Nature ...

Hexanucleotide expansions within intron 1 of the C9ORF72 gene not only lead to the production of toxic products; they also douse the normal expression of the gene. The consequences of this loss play ...

SOUTH SAN FRANCISCO, Calif., March 15, 2022 (GLOBE NEWSWIRE) -- Alector, Inc. (Nasdaq: ALEC), a clinical-stage biotechnology company pioneering immuno-neurology, presented results from the INFRONT-2 ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction.

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA ...

What did Stephen Hawking and Mao Zedong have in common? They both suffered from Amyotrophic Lateral Sclerosis (ALS), a cure for which remains elusive. Scientists from Osaka Metropolitan University ...

The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Researchers from VIB and UAntwerp, headed ...

Alzheimer’s disease gets most of the press for neurodegeneration, but it is not the only devastating neurodegenerative disease out there. Frontotemporal dementia (FTD) and amyotrophic lateral ...

The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Researchers have demonstrated that if an ...