Week 12 of the 2025 college football season continues on Saturday with 22 of the teams ranked in the latest College Football Playoff Rankings in action. This weekend is shaping up to be one of the best slates of the entire season with four ranked-on-ranked matchups on tap.

The No. 21 Iowa Hawkeyes, led by quarterback Mark Gronowski, face the No. 17 USC Trojans, led by quarterback Jayden Maiava on Saturday, Nov. 15, 2025 at Los Angeles Memorial Coliseum in Los Angeles, Calif.

One week after a crushing 18-16 home loss to Oregon that all but eliminated its College Football Playoff dreams, No. 21 Iowa has another tough task on its hands in Week 12. Today's 2:30 p.m. CT date with No. 17 USC gives the Hawkeyes another chance to land their first ranked win since 2021.

Throughout Saturday’s slate, Sports Illustrated will give an updated look at the playoff seeding and matchups.

The Georgia Tech Yellow Jackets, led by quarterback Haynes King, face the Boston College Eagles on Saturday, Nov. 15, 2025 at Alumni Stadium in Chesnut Hill, Mass.

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The Aggies enter Week 12 at 9-0 and holding onto ESPN's No. 3 recruiting class in the 2026 cycle. As coach Mike Elko and Co. continue building on-field momentum, Texas A&M is working on several late moves before the early signing period.